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Senior Associate Genomic Medicines in LMR Cell Technologies

Location
Penzberg, Bayern
Job Type
Permanent
Posted
16 Sep 2022
Senior Associate Genomic Medicines in LMR Cell Technologies
The Position

Senior Associate Genomic Medicines (m/f/d)

Are you ready for your next challenge?

Our vision is to create novel and highly differentiated medicines. To this end, we discover and
develop novel therapeutic antibodies and next generation biologics, such as bispecific
antibodies, fusion proteins or AAV vectors for gene therapy. Our ambition is to deliver such
novel molecules to patients with game changing clinical benefits.
We are looking for a Senior Associate in Genomic Medicine (m/f/d) with a keen interest in the
fields of drug discovery and development. You will join the department of Cell Technologies,
which belongs to a unit called Large Molecule Research within Roche Pharma Research and
Early Development (pRED).

This position therefore offers the opportunity to interact with numerous functions within
Roche to deliver novel medicines to patients.

Your team in a nutshell:

You will be part of ambitious matrix teams, which drive different projects of the Genomic
Medicine in Therapeutic Modalities (TMo). These teams involve Roche colleagues with
different expertise and level (e.g. students, lab technicians, scientists and project managers).
Each voice is valued and we highly appreciate the contribution of different perspectives that
often leads to innovative solutions for our challenging projects.

The job in a nutshell:

Your work focuses on development and application of methods for AAV vector generation for
Gene Therapy. Hereby you will employ synthetic biology tools for cell engineering and
recombinant AAV vector engineering. You have a strong background in molecular biology,
analytical methods, and cell-culture & -engineering. In addition, you can establish methods
that enable design-build-test-learn cycles for the development of advanced AAV vectors.
Moreover, you have strong organizational skills as you will be responsible for structuring and
maintaining lab activities.

The main tasks of this position:

DESIGN: You will design experiments for optimization of AAV-vectors and AAV-vector
production systems (including stable production cell lines) & workflows (including
automated workflows) supported by using methodologies such as used in Synthetic
Biology.
BUILD: You will apply cutting-edge technology to design and create plasmids and
AAV vectors by either using internal capabilities or by using external suppliers.
TEST: You will use existing and establish new functional readouts, e.g. dPCR, FACS,
reporter cell systems, microfluidic systems and NGS for the characterization of
AAV-vectors and AAV-vector production systems and workflows.
LEARN: You will use state-of-the-art data analysis software to analyze and
consolidate large data sets that support informed or AI-guided decision-making for the
next design cycle.
You will be responsible to map standardized biological parts and process large data
sets to fit into our IT infrastructure.

This is also very important for us:

Team player: you are passionate about building strong teams. In your teams, everyone
shares the success while setbacks are viewed as an opportunity to learn. You support
temporary workers and / or interns.
Communication and networking: You know how to proactively build bridges and how to
network in a big organization.
Being courageous: you tackle difficult issues with confidence and you hold things together
during tough times.
Organizational awareness: you see the big picture and have a clear understanding of other
group's business needs.
Continuous learning: you enjoy the challenges of unfamiliar tasks to continuously learn new
things. You seek novel approaches to solve problems and to challenge the status quo.
Presentation skills: you know how to present in a clear and convincing way in front of big
audiences and management boards.

And the technical requirements for this position?
A strong background in cutting-edge technologies for AAV-vector generation and
biology, cell engineering & synthetic biology is necessary for this position.
A University degree in biotechnology, virology, synthetic biology or similar area helps
you to fulfill those tasks.
Ideally, you have already applied your programming skills to analyze large data sets.
Expertise in methods for viral vector generation, purification and characterization are
required.
Expertise in molecular biology (e.g. plasmid design, DNA sequencing) and cell
engineering (transfection, CRISPRa/i, gene tagging) is required. Experience in the
following techniques and readouts are desired: FACS analysis, microfluidic devices,
cell culture automation.
Experience in high throughput or library approaches is a strong plus.
Fluent English language skills are natural to you.
Strong IT and data analysis skills as well.
Initial experience in project management and coordination is a plus.

Your application:
For your application, please keep it simple. We only ask you for an updated CV.
In principle, this position is also suitable for part-time work.

We look forward to receiving your application!

Your contact to us! With people. For people.

Do you need more support?

Our Talent Acquisition Team welcomes your questions. Please send an email to grenzach.germany_talent_acquisition(at)

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Roche at Penzberg, near Munich, employs more than 5,000 people. The site is one of the largest biotechnology centers in Europe and the only Roche site with research, development and production for both Pharmaceuticals and Diagnostics under one roof. From your beginning with Roche, our motivated team will welcome and support you. Numerous opportunities for personal development, flexible work hours, attractive compensation packages and special family assistance programs are available.

Roche is an Equal Opportunity Employer.
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Details

  • Job Reference: 714044515-2
  • Date Posted: 16 September 2022
  • Recruiter: Roche Diagnostics GmbH
  • Location: Penzberg, Bayern
  • Salary: On Application
  • Sector: I.T. & Communications
  • Job Type: Permanent